准教授　　塚本　哲　　　　　English

助教

概　要

　細胞は力を生理応答に変換できます．この機構を活用し，低出力衝撃波による信頼ある医療機器を新たに開発します．

　オリジナルの実験系により，細胞内における力の時系列変化を測定し，併発される生理応答も同時に観察します．

　ただいま，大学院生を募集してます．外部からでも受験可能です．連絡をお待ちしてます．


所　属

　防衛大学校　応用科学群　応用物理学科


連絡先

　メール：tsuka＠nda.ac.jp  ※＠は半角に置き換えてください

　居　室：理工学２号館２階　246号室

　実験室：理工学２号館２階　240号室


専門分野

　細胞物理学

　メカノトランスダクション


学　歴

　2002.3　東京大学工学部機械工学科 卒業　

　2004.3　東京大学大学院工学系研究科（機械工学専攻）修士課程 終了

　2007.3　同 博士課程 終了


職　歴

　2007.4　東京大学 産学官連携研究員

　2008.1　同 特任助教

　2010.7　防衛大学校応用科学群応用物理学科 助教

　2011.9　芝浦工業大学工学部機械工学科 非常勤講師（- 2017.3）

　2015.4　同 講師

　2018.4　同 准教授（現在に至る）

　2018.9　東京電機大学大学院理工学研究科 非常勤講師（現在に至る）


担当講義

　物理学Ⅰ・物理学実験・理工学実験（教養）

　応用物理学演習Ⅰ（専門）

　バイオメカニクス（専門）


研究業績

  1. Shigeru Tada, Masako Hayashi, Masanori Eguchi, Akira Tsukamoto, "High-throughput separation of cells by dielectrophoresis enhanced with 3D gradient AC electric field", Biomicrofluidics, 11 (2017) 064110.
  2. Akira Tsukamoto, Katie R. Ryan, Yusuke Mitsuoka, Katsuko S. Furukawa, Takashi Ushida, "Cellular traction forces increase during consecutive mechanical stretching following traction force attenuation", J. Biomed. Sci. Eng., 12 (2017) 17-00118.
  3. Shigeru Tada, Arisa Nakanishi , Masanori Eguchi , Kengo Ochi , Megumi Baba , Akira Tsukamoto, "Enhancement of Continuous-Flow Separation of Viable/Nonviable Yeast Cells Using a Nonuniform AC Electric Field with Complex Spatial Distribution", Biomicrofluidics, 10 (2016) 034110.
  4. Masanari Hirahara, Akira Tsukamoto, Hiroki Goto, Shigeru Tada, Masayuki Yagi, Yasushi Umemura, "Visible-Light-Induced Morphological Changes of Giant Vesicles by Photoisomerization of a Ruthenium Aqua Complex", Chemistry - A European Journal, 22 (2016) 2590-2594.
  5. Ryo Tachikawa, Akira Tsukamoto, Yuki Monden, Keiichi Nakagawa, Takehiro Ando, Etsuko Kobayashi, Takashi Ushida, Ichiro Sakuma, "Development of Cavitation Bubble Observation System and Application to Study Expansion Waves and Shock Waves", Advanced Biomedical Engineering, Advanced Biomedical Engineering, 4 (2015) 96-104.
  6. Miu Tamamitsu, Keiichi Nakagawa, Ryoichi Horisaki, Atsushi Iwasaki, Yu Oishi, Akira Tsukamoto, Fumihiko Kannari, Ichiro Sakuma, Keisuke Goda, "Design for sequentially timed all-optical mapping photography with optimum temporal performance", Optics Letters, 40 (2015) 633-636.
  7. Aya Shinmura, Akira Tsukamoto, Tsuyoshi Hamada, Kouki Takemura, Takashi Ushida, Shigeru Tada, "Morphological dynamics of mitochondria in bovine aortic endothelial cell under cyclic stretch", Advanced Biomedical Engineering, 4 (2015) 60-66.
  8. Shigeru Tada, Tomoyuki Natsuya, Akira Tsukamoto, "Dielectric Aggregation Kinetics of Cells in a Uniform AC Electric Field", Biorheology, 51 (2014) 381-97.
  9. Keiichi Nakagawa, Atsushi Iwasaki, Yu Oishi, Ryoichi Horisaki, Akira Tsukamoto, Aoi Nakamura, Kenichi Hirosawa, Hongen Liao, Takashi Ushida, Keisuke Goda, Fumihiko Kannari and Ichiro Sakuma, "Sequentially timed all-optical mapping photography (STAMP)", Nature Photonics 8 (2014) 695-700.
  10. Kenji Yoshida, Kazuya Obata, Akira Tsukamoto, Takashi Ushida, Yoshiaki Watanabe, "Evaluation on damage of mimicking tissue caused by a collapsing bubble under low-frequency ultrasound exposure", Ultrasonics 54 (2014) 1603-1609.
  11. Shigeru Tada, Tomoyuki Natsuya, Akira Tsukamoto, and Yudai Santo, "Contactless Cell Trapping by the Use of a Uniform AC Electric Field", Biorheology 50 (2013) 283-303.
  12. Akira Tsukamoto, Kei Tanaka, Tatsuya Kumata, Kenji Yoshida, Yoshiaki Watanabe, Shogo Miyata, Katsuko S. Furukawa, Takashi Ushida, "1-MHz ultrasound enhances internal diffusivity in agarose gels", Applied Acoustics 74 (2013) 1117-1121.
  13. 藤田貴行，塚本哲，多田茂，「第1次自己回帰過程の重ね合わせモデルによる平均血圧変動ゆらぎの解析」，日本機械学会論文集（Ｃ編），79 (2013) 1980-1989．
  14. Keiichi Nakagawa, Akira Tsukamoto, Tatsuhiko Arafune, Hongen Liao, Etsuko Kobayashi, Takashi Ushida, Ichiro Sakuma, "A Miniaturized Shock-wave Device for Mounting on Forceps", J. Biomed. Sci. Eng. 8 (2013) 17-26.
  15. Ryo Tachikawa, Akira Tsukamoto, Keiichi Nakagawa, Tatsuhiko Arafune, Hongen Liao, Etsuko Kobayashi, Takashi Ushida, Ichiro Sakuma, "Development of an expansion wave generator for shock wave therapy", Advanced Biomedical Engineering 1 (2012) 68-73.
  16. Yusuke Mitsuoka, Akira Tsukamoto, Shunsuke Iwayoshi, Katsuko S. Furukawa and Takashi Ushida, "High Time Resolution Time-lapse Imaging Reveals Continuous Existence and Rotation of Stress Fibers under Cyclic Stretch in HUVEC", J. Biomed. Eng. Sci. 7 (2012) 188-198.
  17. 藤田貴行，塚本哲，多田茂，「第一次自己回帰モデルによるゆらぎの解析」，日本機械学会論文集（Ｃ編） 77 (2011) 3017-3024．
  18. Akira Tsukamoto, Satoru Higashiyama, Kenji Yoshida, Yoshiaki Watanabe, Katsuko S. Furukawa, Takashi Ushida, "Stable cavitation induces increased cytoplasmic calcium in L929 fibroblasts exposed to 1-MHz pulsed ultrasound", Ultrasonics 51 (2011) 982-990.　
  19. Atsuhiro Nakagawa, Geoffrey T. Manley, Alisa D. Gean, Kiyonobu Ohtani, Rocco Armonda, Akira Tsukamoto, Hiroaki Yamamoto, Kazuyoshi Takayama, Teiji Tominaga, "Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research", J Neurotrauma 28 (2011) 1101-1119.
  20. 中川敦寛，荒船龍彦，大谷清伸，山本裕朗，松永忠雄，鷲尾利克，塚本哲，中野徹，仲井正昭，合田圭介，小川欣一，孫明宇，隈部俊宏，芳賀洋一，Bahram Jalali，牛田多加志，高山和喜，西野精治，新家光雄，佐久間一郎，冨永悌二，「blast-induced traumatic brain infury (bTBI): multidisciplinary teamによる病態解明から機器開発まで」，神経外傷，33 (2010) 187-194．
  21. Akira Tsukamoto, Yasunori Hayashida, Katsuko S. Furukawa and Takashi Ushida, "Spatio-temporal PLC activation in parallel with intracellular Ca2+ wave propagation in mechanically stimulated single MDCK cells", Cell Calcium 47 (2010) 253・63.
  22. Kenji Yoshida, Shintaro Nakatani, Akira Tsukamoto, Takashi Ushida and Yoshiaki Watanabe,"Effects of Collapsing Bubble in Ultrasonic Field on Soft Material", Jpn. J. Appl. Phys. 47 (2008) 4200-4204.

受　賞

--研　究--
  1. JBSE Graphics of the Year Awards 2017: Akira Tsukamoto, Katie R. Ryan, Yusuke Mitsuoka, Katsuko S. Furukawa, Takashi Ushida, "Cellular traction forces increase during consecutive mechanical stretching following traction force attenuation", J. Biomed. Sci. Eng., 12 (2017) 17-00118.
  2. 平成28年度日本生体医工学会論文賞・阪本賞: Ryo Tachikawa, Akira Tsukamoto, Yuki Monden, Keiichi Nakagawa, Takehiro Ando, Etsuko Kobayashi, Takashi Ushida, Ichiro Sakuma, "Development of Cavitation Bubble Observation System and Application to Study Expansion Waves and Shock Waves", Advanced Biomedical Engineering, Advanced Biomedical Engineering, 4 (2015) 96-104.
  3. 平成26年度防衛大学校学術・教育振興会山崎奨励賞
  4. JBSE Graphics of the Year Awards 2012: Yusuke Mitsuoka, Akira Tsukamoto, Shunsuke Iwayoshi, Katsuko S. Furukawa and Takashi Ushida, "High Time Resolution Time-lapse Imaging Reveals Continuous Existence and Rotation of Stress Fibers under Cyclic Stretch in HUVEC", J. Biomed. Eng. Sci. 7 (2012) 188-198.
  5. JBSE Papers of the Year Awards 2012: Yusuke Mitsuoka, Akira Tsukamoto, Shunsuke Iwayoshi, Katsuko S. Furukawa and Takashi Ushida, "High Time Resolution Time-lapse Imaging Reveals Continuous Existence and Rotation of Stress Fibers under Cyclic Stretch in HUVEC", J. Biomed. Eng. Sci. 7 (2012) 188-198.
  6. 平成24年度日本生体医工学会研究奨励賞・阪本研究刊行助成賞・阿部賞
  7. 平成24年度防衛大学校学術・教育振興会研究奨励賞
  8. 平成23年度衝撃波シンポジウム　Best Presentation Award
  9. 超音波シンポジウム論文賞 (USE2007論文賞)： Kenji Yoshida, Shintaro Nakatani, Akira Tsukamoto, Takashi Ushida and Yoshiaki Watanabe, "Effects of Collapsing Bubble in Ultrasonic Field on Soft Material", Jpn. J. Appl. Phys. 47 (2008) 4200-4204.

--教　育--
  1. 平成26年度芝浦工業大学機械工学科優秀教育推進賞
  2. 平成24年度防衛大学校学術・教育振興会教育奨励賞

所属学会

日本機械学会

日本生体医工学会

国際衝撃波学会