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INFECTIOUS DISEASE RESEARCH PROGRAM

Center for Global Security

Outline of Research

Given the increased likelihood of deployment of Japan Self-Defense Forces abroad for international contribution and peacekeeping missions, the threat to these forces from a variety of diseases not experienced in Japan has become an area of concern.

Ebola hemorrhagic fever and SARS are two examples of these diseases, but there are many other epidemics which also pose a danger. Dealing with these infectious diseases has thus become an urgent priority for this country, and this calls for enhancing study of them from both basic to applied research, and furthermore, to concentrate greater attention on security, prevention and countermeasures.

We intend to analyze infection mechanisms and host cell responses with the latest biological approaches, and explore basic development of protection strategies as well as biological prevention and protection measures. We also plan to focus on research relating to technological measures and practical applications of basic drug development. In addition, we will explore the methodologies of enantioselective synthesis for organic compounds which would protect against bio/chemical terrorism.

Needless to say, the same approach used to deal with infectious disease can also be applied to contending with bio/chemical terrorism. Thus, our research project outcomes can provide broad contributions not only to prevent infection, but also to enhance the security of the general population.

Infectious Disease Research Project

We are working on the following projects.

1Human damage prevention and simulation countermeasure project in cases of large-scale disaster and biological threat

(1) Overview
In addressing large-scale disaster and bioterrorism and emerging infectious diseases, this is an innovative and interdisciplinary research project as: 1) to collect and analyze the historiography from the field of life sciences and study on the scientific measures coping with biological weapons and infectious diseases; 2) to collect and analyze historical records of disasters from geographical and historical fields; 3) to hand them over to computer engineering field to have them to formulate actions of SDF who are involved in minimizing the damage by forecasting diffusion; 4) to conduct a simulation of ultra-wide evacuation which is larger than those on a conventional scale thereby ensuring the security of citizens in such a scenario.

(2) Project Director
Takamasa Uekita, Associate Professor, Department of Applied Chemistry,  School of Applied Sciences, NDA

(3) Research Associates
Kumiko Yamachika, Professor, Department of Humanities,  School of Humanities and Social Sciences, NDA
Shoji Mimura, Associate Professor, Department of Humanities, School of Humanities and Social Sciences, NDA
Hiroshi Sato, Professor, Department of Computer Science, School of Electrical and Computer Engineering, NDA
Masao Kubo, Associate Professor, Department of Computer Science, School of Electrical and Computer Engineering, NDA
Tomohiro Shirakawa, Research Assistant, Department of Computer Science, School of Electrical and Computer Engineering, NDA
Toru Ichimura, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA
Yukihiro Yoshimura, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA
Takahiro Takekiyo,, Associate Professor, Department of Applied Chemistry, School of Applied Sciences, NDA
Advanced Defense Technology Center, Acquisition, Technology & Logistics Agency (ATLA)

2Basic research project on protection of emerging infectious disease and bio/chemical terrorism

(1) Overview
The importance of countermeasures against infectious disease such as Ebola Hemorrhagic fever (which became a global threat) and domestic Dengue fever, and the ones against bio/chemical terrorism, is increasing day by day. In this project, we aim at searching viral infection mechanisms and mechanisms of factors related to bio/chemical terrorism, and establishing of the preventive measures against, and the direct countermeasures toward, such an event at the time of outbreak.

(2) Project Director
Takamasa Uekita, Associate Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

(3) Research Associates
Advanced Defense Technology Center, Acquisition, Technology & Logistics Agency (ATLA) And others

3【Finished】Stereoselective synthesis using new Menthyl asymmetric catalyst

(1) Overview
In recent years, research of preventive disasters against bioterrorism and others, is a major agenda in the world. In this situation, this research project is aiming to find new measures of preventive disasters through viewing the biological body at the molecular structure level, and synthesizing asymmetric compounds streoselectively, and exploring the new catalyst.

(2) Project Director
Kaori Ishimaru, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

4Construction of ultrasensitive protein identification system for infectious disease countermeasures

(1) Overview
This research aims to establish a general and convenient method for protein extraction and digestion from complex biological samples in trace quantities. Moreover, it aims to construct an ultrasensitive protein identification system involving liquid chromatography-mass spectrometry to analyze the proteolytic digests directly.

(2) Project Director
Toru Ichimura, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

(3) Research Associates
Takamasa Uekita, Associate Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

5Basic research on hygiene control in a time of disaster

(1) Overview
As part of securing safety in disaster zones at home and abroad, we aim to prevent health damage caused by microorganisms or microbial produced toxins. We will investigate past cases and do basic research with regards to microorganisms such as bacteria, fungi, parasites and others, in order to reach the best countermeasures.

(2) Project Director
Masami Yamada, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

6Development and reaction of the novel proline catalysts

(1) Overview
Recent years, there are world-wide problems of bioterrorism. In this project, we have develop novel disaster prevention method of molecular structure which is formed by stereoselective synthesis of asymmetric compounds.

(2) Project Director
Kaori Ishimaru, Professor, Department of Applied Chemistry, School of Applied Sciences, NDA

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