原著論文


2010年以降の論文


14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.
Ichimura T, Taoka M, Shoji I, Kato H, Sato T, Hatakeyama S, Isobe T, Hachiya N.
J Cell Sci. 126:2014-2026 (2013).

Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins.
Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K.
Exp Cell Res. 317:2853-2863 (2011).

E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1.
Nasu J, Murakami K, Miyagawa S, Yamashita R, Ichimura T, Wakita T, Hotta H, Miyamura T, Suzuki T, Satoh T, Shoji I.
J Cell Biochem. 111:676-685 (2010).

Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.
Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M.
J Biol Chem. 285:4185-4194 (2010).



2010年以前の主要論文（引用論文数40以上のもの）


Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, Akira S, Noda T, Yoshimori T.
Nat Cell Biol. 11:385-396 (2009).

Proteomic analysis of in vivo 14-3-3 interactions in the yeast Saccharomyces cerevisiae.
Kakiuchi K, Yamauchi Y, Taoka M, Iwago M, Fujita T, Ito T, Song SY, Sakai A, Isobe T, Ichimura T.
Biochemistry 46:7781-7792 (2007).

E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein.
Shirakura M, Murakami K, Ichimura T, Suzuki R, Shimoji T, Fukuda K, Abe K, Sato S, Fukasawa M, Yamakawa Y, Nishijima M, Moriishi K, Matsuura Y, Wakita T, Suzuki T, Howley PM, Miyamura T, Shoji I.
J Virol. 81:1174-1185 (2007).

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y.
EMBO J. 25:5015-5025 (2006).

STEM: a software tool for large-scale proteomic data analyses.
Shinkawa T, Taoka M, Yamauchi Y, Ichimura T, Kaji H, Takahashi N, Isobe T.
J Proteome Res. 4:1826-1831 (2005).

Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases.
Tokumitsu H, Hatano N, Inuzuka H, Sueyoshi Y, Yokokura S, Ichimura T, Nozaki N, Kobayashi R.
J Biol Chem. 280:35108-35118 (2005).

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.
Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T.
J Biol Chem. 280:13187-13194 (2005).

V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.
Taoka M, Ichimura T, Wakamiya-Tsuruta A, Kubota Y, Araki T, Obinata T, Isobe T.
J Biol Chem. 278:5864-5870 (2003).

Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T.
Biochemistry 41:5566-5572 (2002).

Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.
Itagaki C, Isobe T, Taoka M, Natsume T, Nomura N, Horigome T, Omata S, Ichinose H, Nagatsu T, Greene LA, Ichimura T.
Biochemistry 38:15673-15680 (1999).

14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T.
J Biol Chem. 272:25267-25274 (1997).

The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus.
Ichimura T, Ito M, Itagaki C, Takahashi M, Horigome T, Omata S, Ohno S, Isobe T.
FEBS Lett. 413:273-276 (1997).

Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase.
Ichimura T, Uchiyama J, Kunihiro O, Ito M, Horigome T, Omata S, Shinkai F, Kaji H, Isobe T.
J Biol Chem. 270:28515-28518 (1995).

A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons.
Matsuoka K, Taoka M, Satozawa N, Nakayama H, Ichimura T, Takahashi N, Yamakuni T, Song SY, Isobe T.
Proc Natl Acad Sci U S A. 91:9670-9674 (1994).

Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, Isobe T, Ichimura T, Kuwano R, Takahashi Y, Kondo H, Inoue Y.
Mol Brain Res. 25:113-121 (1994).

A single Arabidopsis GF14 isoform possesses biochemical characteristics of diverse 14-3-3 homologues.
Lu G, de Vetten NC, Sehnke PC, Isobe T, Ichimura T, Fu H, van Heusden GP, Ferl RJ.
Plant Mol Biol. 25:659-667 (1994).

Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein.
Furukawa Y, Ikuta N, Omata S, Yamauchi T, Isobe T, Ichimura T.
Biochem Biophys Res Commun. 194:144-149 (1993).

Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system.
Watanabe M, Isobe T, Ichimura T, Kuwano R, Takahashi Y, Kondo H.
Mol Brain Res. 17:135-146 (1993).

Activation of protein kinase C by the 14-3-3 proteins homologous with Exo1 protein that stimulates calcium-dependent exocytosis.
Isobe T, Hiyane Y, Ichimura T, Okuyama T, Takahashi N, Nakajo S, Nakaya K.
FEBS Lett. 308:121-124 (1992).

Molecular cloning of cDNA to rat 14-3-3 eta chain polypeptide and the neuronal expression of the mRNA in the central nervous system.
Watanabe M, Isobe T, Okuyama T, Ichimura T, Kuwano R, Takahashi Y, Kondo H.
Mol Brain Res. 10:151-158 (1991).

Widespread distribution of the 14-3-3 protein in vertebrate brains and bovine tissues: correlation with the distributions of calcium-dependent protein kinases.
Ichimura T, Sugano H, Kuwano R, Sunaya T, Okuyama T, Isobe T.
J Neurochem. 56:1449-1451 (1991).

Identification of a membrane protein responsible for ribosome binding in rough microsomal membranes.
Tazawa S, Unuma M, Tondokoro N, Asano Y, Ohsumi T, Ichimura T, Sugano H.
J Biochem. 109:89-98 (1991).

Distinct forms of the protein kinase-dependent activator of tyrosine and tryptophan hydroxylases.
Isobe T, Ichimura T, Sunaya T, Okuyama T, Takahashi N, Kuwano R, Takahashi Y.
J Mol Biol. 217:125-132 (1991).

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases.
Ichimura T, Isobe T, Okuyama T, Takahashi N, Araki K, Kuwano R, Takahashi Y.
Proc Natl Acad Sci U S A. 85:7084-7088 (1988).

Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II.
Ichimura T, Isobe T, Okuyama T, Yamauchi T, Fujisawa H.
FEBS Lett. 219:79-82 (1987).



著書・総説


プロテオーム研究なるほどQ＆A
市村　徹
バイオテクノロジージャーナル（羊土社）3巻、373-375 (2006)

14-3-3タンパク質ファミリーの分子認識とシグナル伝達系での役割
市村　徹、礒辺俊明
実験医学（羊土社）18巻、18-22 (2000)

14-3-3, 細胞内シグナリングを調節する新しいタンパク質ファミリー
市村　徹、礒辺俊明
生化学（日本生化学会）67巻、1156-1162 (1995)


その他15編



学会発表


14-3-3とHsp70/90によるTRIM32タンパク質の安定化
河口祐樹、市村　徹、加藤大樹、西島佳奈、八谷如美
第86回日本生化学会（2013）

Phosphorylation-dependent interaction of argonaute 1 with the 14-3-3 protein
Y.Kawaguchi, T.Ichimura, and R.Niwa
第３５回日本分子生物学会（2012）

A Regulatory Mechanism for Tripartite-motif Protein 32 Revealed by Quantitative 14-3-3 Interactome Analysis in PKA signaling Pathways.
T.Ichimura, I.Shoji, and N.Hachiya
第34回日本分子生物学会（2011）

E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1.
S.Ikuo, J.Nasu, K.Murakami, S.Miyagawa, R.Yamashita, T.Ichimura, T. Wakita, Y.Ide, H.Hotta, T.Miyamura, T.Suzuki, and T.Satoh
第33回日本分子生物学（2010）


その他100件以上